- Date: 03/05-03/06/10
- Location: Notre Dame-Loftus Center - Notre Dame, IN
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- ICON KEY:
Women's 4 x 400 Relay
- Finals: Heat #1
| Place | Overall | Team | Squad | Athletes | Time | Score |
| 1. | 1 | Mississippi | A | Jasmine Dacus, Kristin Bridges, Sofia Hellberg-Jonsen, Sofie Persson | 3:35.40 | - | |
| 2. | 2 | Georgetown | A | Amanda Kimbers, Nene Kamate, Abigail Johnson, London Finley | 3:35.64 | - | |
| 3. | 3 | Florida | A | Alishea Usery, Danielle Williams, Lanie Whittaker, Ije Iheoma | 3:35.95 | - | |
| 4. | 4 | Kansas | A | Denesha Morris, Taissa Makhamayva, Shayla Wilson, Taylor Washington | 3:37.80 | - | |
| 5. | 5 | Western Michigan | A | Ashley Hunault, Victoria Chatman, Iris Campbell, Leya Munwam | 3:39.53 | - | |
| 6. | 6 | Wisconsin | A | 3:45.55 | - |