- Date: 02-19-10
- Location: Eastern Illinois-Lantz FH - Charleston, IL
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- ICON KEY:
| Place | Overall | Team | Squad | Athletes | Time | Score |
| 1. | 1 | Rend Lake | A | Andrew Hendrix, Jarius Gibson, Stephen Murphy, Malik Fair | 3:19.37 | - | |
| 2. | 2 | Eastern Illinois | A | Darren Patterson, Sean Wiggan, Wes Sheldon, Marcus Williams | 3:19.45 | - | |
| 3. | 4 | Eastern Illinois | B | Chad Aubin, Justin Stewart, Marvin Cosby, Reid Basting | 3:26.68 | - | |
| 4. | 5 | Florissant Valley CC | A | Antoine Robinson, John Lawson, Alexander Allen, Brandon McElroy | 3:31.81 | - |