| 1. | 6. | Hannibal-LaGrange | Columbia (Mo.) | McKinley Christopherson, Leslie Case, Elle Hudelson, Lindsey Lebel | Emily Weiss, Hope Cram, Anne Yepes, Kyla Downes | 8:10:37.876 | 8:13:05.6080 | 081043 | 006 |
| 2. | 1. | Missouri Baptist | William Woods | Alyssa Jakcsy, Ansley Little, Alexandra Perry, Erin Tomschin | Alyssa Jakcsy, Ansley Little, Alexandra Perry, Erin Tomschin | 52:10:40.0911 | 28:11:24.541 | 2482 | 2482 |
| 3. | 3. | William Woods | Williams Baptist | Faith Gerling, Katie Keath, Kristan Wilson, Alessa Cremer | Jena Hahlbeck, Allison Gibson, Marina Rios, Jasmine Banks | 10:50.672 | 8:13:05.6080 | 006 | 2 |
| 4. | 1. | Columbia (Mo.) | Missouri Baptist | Naomi Payne, Daylin Huebotter, Megan Korte, Madalyn Ford | McKinley Christopherson, Leslie Case, Elle Hudelson, Lindsey Lebel | 48:10:54.266 | 8:10:37.876 | 35 | 006 |
| 5. | 5. | Park U. | William Woods | Jena Hahlbeck, Allison Gibson, Marina Rios, Jasmine Banks | Haeley Pines, Daisy Connor, Rachel Jones, Alexandria Nagle | 36:10:58.369 | 10:50.672 | 4 | 35 |
| 6. | 4. | Lyon | William Woods | Haeley Pines, Daisy Connor, Rachel Jones, Alexandria Nagle | Faith Gerling, Katie Keath, Kristan Wilson, Alessa Cremer | 28:11:24.541 | 8:13:05.6080 | 33 | 2 |
| 7. | 2. | Williams Baptist | Columbia (Mo.) | Emily Weiss, Hope Cram, Anne Yepes, Kyla Downes | Naomi Payne, Daylin Huebotter, Megan Korte, Madalyn Ford | 8:13:05.6080 | 28:11:24.541 | 2 | 2 |
